2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. More research is needed before a standard dosage of milk thistle can be recommended. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Verywell Health's content is for informational and educational purposes only. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . The name milk thistle is associated with the legend of Mother Mary. Who should not take Milk Thistle Capsule? However, the extracts in milk thistle could act like estrogen. Other studies looking at milk thistle for cirrhosis have found conflicting results. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. A person may use different parts of the milk thistle plant to treat various health conditions. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Silymarin is an active compound found in milk thistle seeds. There are no guidelines regarding a standard dose of milk thistle. Medical research on milk thistle and liver health has led to mixed results. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Learn more about the other negative effects of this herb and what research says about them. Keep all medications and herbal products away from children and pets. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Does milk thistle cause any side effects? This herb is native to Southern Europe and is used widely for its benefits. Milk Thistle; Silybum marianum; St. Mary's Thistle. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Spiny stems branch at the top and reach heights of 5 to 10 feet. Milk thistle could play an essential role in supporting bone health. Eur Endocrinol. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. What Are the Side Effects of Milk Thistle? These reactions may occur if you have an allergy to milk thistle. Milk thistle is sold as an oral capsule, tablet and liquid extract. Some of the studies have been of poor quality, too. Its seed might protect liver cells from toxic chemicals and drugs. In:Drugs and Lactation Database (LactMed). 2012;308(3):274-282. doi:10.1001/jama.2012.8265. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. We include products we think are useful for our readers. Hence, limit its usage if you experience any adverse reactions. Can you drink alcohol while taking milk thistle? Consult your doctor before breast-feeding. Review provided by VeriMed Healthcare Network. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. (2021). Take your next dose at the regular time. World J Gastroenterol. Certain individuals might experience weakness with milk thistle. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? It is now found throughout the world. This product is not recommended for use during pregnancy. In one case, milk thistle had caused excessive sweating and weakness (14). In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. You should follow dosage directions to prevent side effects. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. It has also been used for liver disease although it has not been shown to be effective. Milk thistle ( Silybum marianum L. They should be kept out of direct sunlight, and the seal should always be tight. Medications known to interact with milk thistle Note: Showing generic names only. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Yes, you can drink alcohol while taking milk thistle. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. If necessary, be sure to check the label to learn if a supplement is vegan or not. 2005 - 2023 WebMD LLC. Although rare, milk thistle may trigger a number of common and mild side effects. Olive Oil Vs. Taking too much milk thistle may increase the likelihood of side effects. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. Call your doctor for medical advice about side effects. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Adv Ther. Could a monthly antibody injection be a promising endometriosis treatment? Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. Milk thistle is also available as a tea. However, there is no solid evidence that supports these claims. StatPearls Publishing; 2022. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Loose stools or upset stomach may occur. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). gallbladder disorders. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Can diet help improve depression symptoms? We encourage you to discuss any decisions about treatment or care with your health care provider. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. A double-blind controlled study. Include all brand names and combination drug names. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Possibly. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Before using this product, tell your doctor or pharmacist of all the products you use. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. Milk thistle (PDQ) health professional version. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. J Diabetes Res. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). What Is Complementary, Alternative, or Integrative Health? This document does not contain all possible interactions. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). This is not a complete list of side effects and others may occur. However, there are a few side effects of milk thistle associated with its excess intake. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 1982;17:51721. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. How long does it take for milk thistle to start working? Natural Medicines website. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. More study is needed to confirm this. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Historically, people have used milk thistle for liver disorders and gallbladder problems. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. No supplement is intended to treat, cure, or prevent disease. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. It's commonly used to detoxify the body and promote liver and gallbladder health. StyleCraze provides content of general nature that is designed for informational purposes only. So, consult a doctor to understand about its long term usage. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. 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